Towards Predicting Gut Microbial Metabolism: Integration of Flux Balance Analysis and Untargeted Metabolomics
نویسندگان
چکیده
منابع مشابه
Untargeted metabolomics.
Along with genes and proteins, metabolites play important roles in sustaining life. Their functions include "primary" functions in metabolism and energy storage, as well as "secondary" functions in cell-to-cell signaling, metal acquisition, and virulence. There remains much to be learned about the in vivo roles of metabolites. Approaches that accelerate measurement of metabolite levels directly...
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Flux balance analysis (FBA) has emerged as an effective means to analyse biological networks in a quantitative manner. Much progress has been made on the extension of FBA to incorporate a priori biological knowledge, provide more practical descriptions of observed cell behaviours, and predict the outcome of network perturbations. Metabolomics is independently advancing as a set of high-throughp...
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Introduction: Untargeted metabolomics is a powerful tool for biological discoveries. Significant advances in computational approaches to analyzing the complex raw data have been made, yet it is not clear how exhaustive and reliable are the data analysis results. Objectives: Assessment of the quality of data analysis results in untargeted metabolomics. Methods: Five published untargeted metabolo...
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A central focus in studies of microbial communities is the elucidation of the relationships between genotype, phenotype, and dynamic community structure. Here, we present a new computational method called community flux balance analysis (cFBA) to study the metabolic behavior of microbial communities. cFBA integrates the comprehensive metabolic capacities of individual microorganisms in terms of...
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Mass spectrometry-based untargeted metabolomics often results in the observation of hundreds to thousands of features that are differentially regulated between sample classes. A major challenge in interpreting the data is distinguishing metabolites that are causally associated with the phenotype of interest from those that are unrelated but altered in downstream pathways as an effect. To facili...
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ژورنال
عنوان ژورنال: Metabolites
سال: 2020
ISSN: 2218-1989
DOI: 10.3390/metabo10040156